Enantioselective Functionalization of Enamides at the Beta-Carbon Center with Indoles

Abstract

We report a novel enantioconvergent approach to functionalize enamides at the beta‐carbon, highlighted by chiral Brønsted acid‐induced tautomerization of 2‐amidoallyl to 1‐amidoallyl cations. These putative reactive intermediates were produced via ionization of racemic alpha‐hydroxy enamides with a chiral Brønsted acid and captured by substituted indoles in a highly regio‐ and enantioselective manner.

Publication
In Angewandte Chemie International Edition
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